
Our Team
Our founder
Dr Jeff Moore
Dr Moore’s career has focused on the regulation of cell production in the body’s two most regenerative tissues: the bone marrow and the single layer of the intestinal mucosa. He holds a PhD in genetics from George Washington University and has spent over 40 years researching cell production and developing novel treatments. Dr Moore founded Phylogix Inc and led the discovery and development of a protein (FRIL) through to late preclinical development.
Dr Jeff Moore
Founder and CEO
Dr Moore’s career has focused on the regulation of cell production in the body’s two most regenerative tissues: the bone marrow and the single layer of the intestinal mucosa.
His PhD research conducted at the US National Institutes of Health (NIH) changed the understanding of the genetic basis of paroxysmal nocturnal haemaglobinuria (PNH).[i]
Dr Moore’s search for regulators of cell production started as a post-doctoral fellow of Dr Don Metcalf at the Walter and Elisa Hall Institute (WEHI) in Melbourne, founder of the field of blood cell production.
Based on some early research, Dr Moore set out at WEHI to identify the body’s regulators that protect stem cells (engine for cell production) from the toxicity of chemotherapy. The search continued at DNAX Research Institute in Palo Alto and at ImClone Systems Inc in New York City.
At ImClone, Dr Moore discovered a protein (FRIL) that maintained blood stem cells in culture for extended periods and were capable of repopulating long-term blood cell production. He founded Phylogix Inc in the Boston area and advanced FRIL to late preclinical development with $15m venture capital funding from Atlas Venture, Biotechnology Value Fund, Canaan Partners, Prospect Venture Partners and Radius Ventures.
Dr Moore then moved to the body’s other most regenerative tissue, the mucosal layer of the gut. He joined Prof Chris Potten, founder of the epithelial stem cell field, at Epistem Ltd in Manchester, UK. Dr Moore created and led a regenerative medicine collaboration with Novartis Institutes of BioMedical Research (NIBR), where his team developed and validated in vitro models that delivered the core technology at Curileum.
Dr Moore graduated from Colorado College with a BA in chemistry and from George Washington University with a PhD in genetics.
[i] https://pubmed.ncbi.nlm.nih.gov/2413153/

The team
Our expert team
Curileum is guided by an experienced team of scientific and clinical advisors.
Team
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Mohini Kalyan
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Mohini Kalyan
Lead Scientist
A highly experienced Senior Scientist who has contributed significantly to several publications including those published in Cell, the Journal of Clinical Investigation and the Lancet. Experience at Synexa Life Sciences and Imperial College London.
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Andy Baxter
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Andy Baxter
Consultant in Drug Development
Andy Baxter has extensive experience in drug development across academia and industry, with expertise spanning translational pharmacology, clinical trial design, and regulatory strategy. He provides strategic guidance on development pathways, helping bridge early-stage science with clinical and commercial goals.
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Julie Warneck
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Julie Warneck
Consultant in Non-clinical Development
Julie Warneck is a specialist in non-clinical development, with deep expertise in toxicology, pharmacology, and IND/CTA-enabling studies. She advises on preclinical strategy, regulatory submissions, and the integration of laboratory findings into development programs.
Scientific Advisory Board
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Darren Dixon
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Darren Dixon
Prof. University of Oxford, CSO & Founder, Cortex Organics Ltd
Darren Dixon is Professor of Chemistry at Oxford and a leading figure in synthetic methodology. As CSO and Founder of Cortex Organics, he pioneers novel synthetic routes to complex molecules. His work bridges academic discovery with commercial application in drug development.
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Yao Shi
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Yao Shi
CEO & Founder, Cortex Organics
Yao Shi is a chemist and entrepreneur, serving as CEO and Founder of Cortex Organics. With a PhD in synthetic chemistry, he has developed innovative strategies for scalable synthesis of complex molecules. Yao leads Cortex in supporting pharma and biotech partners with bespoke chemistry solutions.
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Paul Brennan
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Paul Brennan
Prof. University of Oxford, Director, Centre for Medicines Discovery
Paul Brennan is Professor of Medicinal Chemistry at Oxford and Director of the Centre for Medicines Discovery. His research focuses on chemical biology and drug discovery, particularly developing small molecules to probe disease pathways. He has extensive experience translating academic discovery into therapeutic innovation.
Clinical Advisory Board
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Sir John Burn
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Sir John Burn
Prof, Newcastle University, Fellow, Academy of Medical Sciences
Sir John Burn is Professor of Clinical Genetics at Newcastle University and a Fellow of the Academy of Medical Sciences. A global authority in hereditary cancer syndromes, he has pioneered research and clinical practice in genomics, cancer prevention, and precision medicine.
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Karen Brown
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Karen Brown
Prof, University of Leicester, Co-Founder, COLO-PREVENT
Karen Brown is Professor of Translational Cancer Research at the University of Leicester and Co-Founder of COLO-PREVENT. Her work focuses on chemoprevention and biomarker-driven clinical trials, advancing strategies to prevent colorectal and other cancers.
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Mark Hull
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Mark Hull
Prof, University of Leeds, Co-Founder, COLO-PREVENT
Mark Hull is Professor of Molecular Gastroenterology at the University of Leeds and Co-Founder of COLO-PREVENT. His research emphasizes colorectal cancer prevention, inflammation-associated carcinogenesis, and translational clinical trials designed to test preventive interventions.